Publication

発表論文

2016

R. Watanabe, N. Soga, M. Hara and H. Noji
Arrayed water-in-oil droplet bilayers for membrane transport analysis
(2016) Lab Chip., 16, 3043-304
published online

M. Baba, K. Iwamoto, R. Iino, H. Ueno, M. Hara, A. Nakanishi, J. Kishikawa, H. Noji and K. Yokoyama
Rotation of artificial rotor axles in rotary molecular motors
(2016) Proc. Natl. Acad. Sci. USA, 113, 11214-11219
published online

D.G.G. McMillan, R. Watanabe, H. Ueno, G.M. Cook and H. Noji
Biophysical Characterization of a Thermoalkaliphilic Molecular Motor with a High Stepping Torque Gives Insight into Evolutionary ATP Synthase Adaptation
(2016) J. Biol. Chem., 291, 23965-23977
published online

2015

R. Watanabe, N. Soga and H. Noji
Novel Nano-Device to Measure Voltage-Driven Membrane Transporter Activity
(2015) IEEE Transactions on Nanotechnology, 15, 70-73
published online

R. Hayashi, K. Sasaki, S. Nakamura, S. Kudo, Y. Inoue, H. Noji and K. Hayashi
Giant Acceleration of diffusion observed in a single-molecule experiment on F1-ATPase
(2015) Phys. Rev. Lett., 114, 248101
published online

Y. Obayashi, R. Iino and H. Noji
A single-molecule digital enzyme assay using alkaline phosphatase with a cumarin-based fluorogenic substrate
(2015) Analyst, 140, 5065-5073
published online

N. Soga, R. Watanabe and H. Noji
Attolitre-sized lipid bilayer chamber array for rapid detection of single transporters
(2015) Sci. Rep., 5, 11025
published online

H. Fujita, T. Esaki, T. Masujima, S.H. Kim, H. Noji and T. M. Watanabe
Comprehensive chemical secretory measurement of single cell trapped in micro-droplet array with mass spectrometry
(2015) RSC Adv., 5, 16968-16971
published online

S. Enoki, R. Iino, Y. Niitani, Y. Minagawa, M. Tomishige and H. Noji
High-speed angle-resolved imaging of single gold nanorod with microsecond temporal resolution and one-degree angle precision
(2015) Ana. Chem., 87, 2079-2086
published online

R. Watanabe, K. Koyasu, H. You, M. Tanigawara and H. Noji
Torque transmission mechanism via DELSEED loop of F1-ATPase
(2015) Biophys. J., 108, 1144-1152
published online

2014

A. Yukawa, R. Iino, R. Watanabe, S. Hayashi and H. Noji
Key Chemical Factors of Arginine Finger Catalysis of F1-ATPase Clarified by an Unnatural Amino Acid Mutation
(2014) Biochemistry, 54, 472-480
published online

R. Watanabe, N. Soga, T. Yamanaka and H. Noji
High-throughput formation of lipid bilayer membrane arrays with an asymmetric lipid composition
(2014) Sci. Rep., 4, 7076
published online

H. Ueno, Y. Minagawa, M. Hara, R. Suhaila, I. Yamato, E. Muneyuki, H. Noji, T. Murata and R. Iino
Torque generation of Enterococcus hirae V-ATPase
(2014) J. Biol. Chem., 289, 31212-31223
published online

R. Watanabe, Y. Minagawa and H. Noji
Thermodynamic analysis of F1-ATPase rotary catalysis using high-speed imaging
(2014) Protein Sci., 23, 1773-1779
published online

H. Yaginuma, S. Kawai, K.V. Tabata, K. Tomiyama, A. Kakizuka, T. Komatsuzaki, H. Noji and H. Imamura
Diversity in ATP concentrations in a single bacterial cell population revealed by quantitative single-cell imaging.
(2014) Sci. Rep., 4, 6522
published online

J. Kishikawa, A. Seino, A. Nakanishi, N.E. Tirtom, H. Noji, K. Yokokawa and K. Hayashi
F-subunit reinforces torque generation in V-ATPase
(2014) Eur. Biophys. J., 43, 8, 415-422
published online

R. Watanabe*, N. Soga*, D. Fujita*, K.V. Tabata, L. Yamauchi, S.H. Kim, D. Asanuma, M. Kamiya, Y. Urano, H. Suga and H. Noji (*equal contributions)
Arrayed Lipid Bilayer Chambers Allow Single-Molecule Analysis of Membrane Transporter Activity
(2014) Nat. Commun., 5, 4519
published online

R. Watanabe, Y. Matsukage, A. Yukawa, K.V. Tabata and H. Noji
Robustness of the Rotary Catalysis Mechanism of F1-ATPase
(2014) J. Biol. Chem., 289, 19331-19340
published online

T. Ikeda, T. Tsukahara, R. Iino, M. Takeuchi and H. Noji
Motion Capture and Manipulation of Single Synthetic Molecular Rotors by Optical Microscopy
(2014) Angew. Chem., 53, 10082-10085
published online  

T. Ikeda, R. Iino and H. Noji
Real-Time Fluorescence Visualization of Slow Tautomerization of Single Free-Base Phthalocyanines under Ambient Conditions
(2014) Chem. Commun., 50, 9443-9446
published online  

H.C. Arai, A. Yukawa, J.R. Iwatate, M. Kamiya, R. Watanabe, Y. Urano and H. Noji
Torque generation mechanism of F1-ATPase upon NTP binding
(2014) Biophys. J., 107, 156-164
published online

T. Tanaka, K. Nagashima, N. Inagaki, H. Kioka, S. Takashima, H. Fukuoka, H. Noji, A. Kakizuka and H. Imamura
Glucose-stimulated Single Pancreatic Islets Sustain Increased Cytosolic ATP Levels during Initial Ca2+ Influx and Subsequent Ca2+ Oscillations
(2014) J. Biol. Chem., 289, 2205-2216
published online

R. Watanabe and H. Noji
Characterization of the temperature-sensitive reaction of F1-ATPase by using single molecule manipulation
(2014) Sci. Rep., 4, 4962
published online

Y. Shibafuji, A. Nakamura, T. Uchihashi, N. Sugimoto, S. Fukuda, H. Watanabe, M. Samejima, T. Ando, H. Noji, A. Koivula, K. Igarashi and R. Iino
Single-molecule imaging analysis of elementary reaction steps of Trichoderma Reesei cellobiohydrolase I (Cel7A) hydrolyzing crystalline cellulose Iα and IIII
(2014) J. Biol. Chem., 289, 14056-14065
published online

R. Watanabe and H. Noji
Timing of inorganic phosphate release modulates the catalytic activity of ATP-driven rotary motor protein
(2014) Nat. Commun., 5, 3486
published online

2013

S.H. Kim, X. He, S. Kaneda, J. Kawada, D. Fourmy, H. Noji and T. Fujii
Quantifying genetically inserted fluorescent protein in single iPS cells to monitor Nanog expression using electroactive microchamber arrays
(2013) Lab Chip, 14, 730-736
published online

H. Kioka, H. Kato, M. Fujikawa, O. Tsukamoto, T. Suzuki, H. Imamura, A. Nakano, S. Higo, S. Yamazaki, T. Matsuzaki, K. Tkafuji, H. Asanuma, M. Asakura, T. Minamino, Y. Shintani, M. Yoshida, H. Noji, M. Kitakaze, I. Komuro, Y. Asano and S. Takashima
Evaluation of intra-mitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation
(2013) Proc. Natl. Acad. Sci. USA, 111, 273-278
published online

R. Watanabe, K. Hayashi, H. Ueno and H. Noji
Catalysis-enhancement via rotary fluctuation of F1-ATPase
(2013) Biophys. J., 105, 2385-2391
published online

Y. Minagawa, H. Ueno, M. Hara, Y. Ishizuka-Katsura, N. Ohsawa, T. Terada, M. Shirouzu, S. Yokoyama, I. Yamato, E. Muneyuki, H. Noji, T. Murata and R. Iino
Basic properties of rotary dynamics of the molecular motor Enterococcus hirae V1-ATPase
(2013) J. Biol. Chem., 288, 45, 32700-32707
published online

D. Okuno, M. Nishiyama and H. Noji
Single molecule analysis of the rotation of F1-ATPase under high hydrostatic pressure
(2013) Biophys. J., 105, 1635-1642
published online

M. Toei and H. Noji
Single-molecule analysis of FoF1-ATP synthase inhibited by N,N-dicyclohexylcarbodiimide
(2013) J. Biol. Chem., 288, 25717-25726
published online

T. Tsuyama, J. Kishikawa, Y.W. Han, Y. Harada, A. Tsubouchi, H. Noji, A. Kakizuka, K. Yokoyama, T. Uemura and H. Imamura
In vivo fluorescent ATP imaging of Drosophila melanogaster and Caenorhabditis elegans by using a genetically encoded fluorescent ATPbiosensor optimized for low temperatures
(2013) Anal. Chem., 85, 7889-7896
published online

R. Watanabe, K.V. Tabata, R. Iino, H. Ueno, M. Iwamoto, S. Oiki, H. Noji
Biased Brownian stepping rotation of FoF1-ATP synthase driven by proton motive force
(2013) Nat. Commun., 4, 1631
published online

2012

N.E. Tirtom, D. Okuno, M. Nakano, K. Yokoyama and H. Noji
Mechanical Modulation of ATP-Binding Affinity of V1-ATPase
(2012) J. Biol. Chem., 288, 619-623
published online

T. Muraoka, T. Shima, T. Hamada, M. Morita, M. Takagi, K.V. Tabata, H. Noji and K. Kinbara
Ion Permeation by a Folded Multiblock Amphiphilic Oligomer Achieved by Hierarchical Construction of Self-Assembled Nanopores
(2012) J. Am. Chem. Soc., 134, 48, 19788-19794
published online

S. Enoki, R. Iino, N. Morone, K. Kaihatsu, S. Sakakihara, N. Kato and H. Noji
Label-free single-particle imaging of the influenza virus by objective-type total internal reflection dark-field microscopy
(2012) PLoS ONE 7, e49208
published online

N. Hatsugai, V.P. Koldenkova, H. Imamura, H. Noji and T. Nagai
Changes in Cytosolic ATP Levels and Intracellular Morphology during Bacteria-Induced Hypersensitive Cell Death as Revealed by Real-Time Fluorescence Microscopy Imaging
(2012) Plant Cell Physiol., 53, 1768-1775
published online

S.H. Kim, S. Iwai, S. Araki, S. Sakakihara, R. Iino and H. Noji
Large-scale femtoliter droplet array for digital counting of single biomolecules.
(2012) Lab Chip, 12, 4986-4991
published online

M. Tanigawara, K.V. Tabata, Y. Ito, J. Ito, R. Watanabe, H. Ueno, M. Ikeguchi and H. Noji
Role of the DELSEED Loop in Torque Transmission of F1-ATPase.
(2012) Biophys. J., 103, 970-978
published online

N.E. Tirtom, Y. Nishikawa, D. Okuno, M. Nakano, K. Yokoyama and H. Noji
Single-molecule analysis of inhibitory pausing states of V1-ATPase.
(2012) J. Biol. Chem., 287, 28327-28335
published online

H. You, R. Iino, R. Watanabe and H. Noji
Winding single-molecule double-stranded DNA on a nanometer-sized reel.
(2012) Nucleic Acids Res., 40, e151
published online

R. Iino, K. Hayama, H. Amezawa, S. Sakakihara, S.H. Kim, Y. Matsumono, K. Nishino, A. Yamaguchi and H. Noji
A single-cell drug efflux assay in bacteria by using a directly accessible femtoliter droplet array
(2012) Lab Chip, 12, 3923-3929
published online

S. Hayashi, H. Ueno, A.R. Shaikh, M. Umemura, M. Kamiya, Y. Ito, M. Ikeguchi, Y. Komoriya, R. Iino and H. Noji
Molecular mechanism of ATP hydrolysis in F1-ATPase revealed by molecular simulations and single molecule observations
(2012) J. Am. Chem. Soc., 134, 8447-8454
published online

Y. Komoriya, T. Ariga, R. Iino and H. Noji
Principle role of the arginine finger in rotary catalysis of F1-ATPase
(2012) J. Biol. Chem., 287, 15134-15142
published online

K. Sasagawa, K. Ando, T. Kobayashi, T. Noda, T. Tokuda, S.H. Kim, R. Iino, H. Noji and J. Ohta
Complementary Metal–Oxide–Semiconductor Image Sensor with Microchamber Array for Fluorescent Bead Counting
(2012) Jpn. J. Appl. Phys., 51, 02BL01
published online  

2011

R. Watanabe, D. Okuno, S. Sakakihara, K. Shimabukuro, R. Iino, M. Yoshida and H. Noji
Mechanical modulation of catalytic power on F1-ATPase
(2011) Nat. Chem. Biol., 8, 86-92
published online  

J. Kishikawa, M. Fujikawa, H. Imamura, K. Yasuda, H. Noji, N. Ishii, S. Mitani and K. Yokoyama
Expression of ATP sensor protein in Caenorhabditis elegans
(2011) Microscopy Research and Technique 2011
published online

T. Uchihashi, R, Iino, T. Ando and H. Noji
High-speed atomic force microscopy reveals rotary catalysis of rotorless F1-ATPase
(2011) Science, 333, 755-758
published online  

S. Furuike, M. Nakano, K. Adachi, H. Noji, K. Kinosita Jr. and K. Yokoyama
Resolving stepping rotation in Thermus thermophilus H+-ATPase/synthase with an essentially drag-free probe
(2011) Nat. Commun., 2, 233
published online

M. Nakano, H. Imamura, T. Nagai and H. Noji
Ca2+ regulation of mitochondrial ATP synthesis visualized at the single cell level
(2011) ACS Chem. Biol., 6, 709-715
published online

Y. Matsumoto, K. Hayama, S. Sakakihara, K. Nishino, H. Noji, R. Iino and A. Yamaguchi
Evaluation of multidrug efflux pump inhibitors by a new method using microfluidic channels
(2011) PLoS ONE, 6, e18547
published online

2010

S. Sakakihara, S. Araki, R. Iino and H. Noji
A single-molecule enzymatic assay in a directly accessible femtoliter droplet array
(2010) Lab Chip, 10, 3355-3362
published online

R. Watanabe, R. Iino and H. Noji
Phosphate-release in F1-ATPase catalytic cycle follows ADP release
(2010) Nat. Chem Biol., 6, 814-820
published online  

D. Okuno, R. Iino, and H. Noji
Stiffness of γ subunit of F1-ATPase
(2010) Eur. Biophys. J., 39, 1589-1596
published oneline

K. Hayashi, H. Ueno, R. Iino and H. Noji
Fluctuation theorem applied to F1-ATPase
(2010) Phys. Rev. Lett., 104, 218103
published online

H. Ueno, S. Nishikawa, R. Iino, K.V. Tabata, S. Sakakihara, T. Yanagida and H. Noji
Simple Dark-Field Microscopy with Nanometer Spatial Precision and Microsecond Temporal Resolution
(2010) Biophys. J., 98, 2014-2023
published online

T. Ide, Y. Takeuchi, H. Noji and K.V. Tabata
Simultaneous Optical and Electrical Single Channel Recordings on a PEG Glass
(2010) Langmuir, 26, 8540-8543
published online

I. Kotera, T. Iwasaki, H. Imamura, H. Noji and T. Nagai
Reversible dimerization of Aequorea victoria fluorescent proteins increases the dynamic range of FRET-based indicators
(2010) ACS Chem. Biol., 5, 215-222
published online

2009

S.W. Lee, H. Kinoshita, H. Noji, T. Fujii and T. Yamamoto
Biomolecular Nano-Flow-Sensor to Measure Near-Surface Flow
(2009) Nanoscale Res. Lett., 5, 296–301
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T. Nakayama, M. Namura, K.V. Tabata, H. Noji and R. Yokokawa
Protein assay using diffusion effect in single molecule micro-TAS
(2009) Lab Chip, 9, 3567-3573
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Y. Iko, K.V. Tabata, S. Sakakihara, T. Nakashima and H. Noji
Acceleration of the ATP-binding rate of F1-ATPase by forcible forward rotation.
(2009) FEBS Lett., 583, 3187-3191
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K.V. Tabata, K. Sato, T. Ide, T. Nishizaka, A. Nakano and H. Noji
Visualization of cargo concentration by COPII minimal machinery in a planar lipid membrane
(2009) EMBO J., 28, 3279-3289
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H. Imamura, K.P. Huynh Nhat, H. Togawa, K. Saito, R. Iino, Y. Kato-Yamada, T. Nagai and H. Noji
Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators.
(2009) Proc. Natl. Acad. Sci. USA, 106, 15651-15656
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S. Enoki, R. Watanabe, R. Iino and H. Noji
Single-molecule study on the temperature-sensitive reaction of F1-ATPase with a hybrid F1 carrying a single beta(E190D)
(2009) J. Biol. Chem., 284, 23169-13176
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Y. Hirono-Hara, H. Noji and S. Takeuchi
Single-biomolecule observation with micro one-way valves for rapid buffer exchange.
(2009) J. Appl. Phys., 105, 102016
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R. Iino, R. Hasegawa, K.V. Tabata and H. Noji
Mechanism of inhibition by C-terminal alpha-helices of the epsilon subunit of Escherichia coli FoF1-ATP synthase.
(2009) J. Biol. Chem., 284, 17457-17464
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2008

D. Okuno, R. Fujisawa, R. Iino, Y. Hirono-Hara, H. Imamura and H. Noji
Correlation between the conformational states of F1-ATPase as determined from its crystal structure and single-molecule rotation.
(2008) Proc. Natl. Acad. Sci. USA, 105, 20722-20727
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S. Matsumoto, S. Yamaguchi, S. Ueno, H. Komatsu, M. Ikeda, K. Ishizuka, Y. Iko, K.V. Tabata, H. Aoki, S. Ito, H. Noji and I. Hamachi
Photo Gel-Sol/Sol-Gel Transition and Its Patterning of a Supramolecular Hydrogel as Stimuli-Responsive Biomaterials.
(2008) Chem. Eur. J., 14, 3977-398
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L. Lam, S. Sakakihara, K. Ishizuka, S. Takeuchi, H.F. Arata, H. Fujita and H. Noji
Loop-mediated isothermal amplification of a single DNA molecule in polyacrylamide gel-based microchamber.
(2008) Biomed. Microdevices., 10, 539-546
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R. Watanabe, R. Iino, K. Shimabukuro, M. Yoshida and H. Noji
Temperature-sensitive reaction intermediate of F1-ATPase.
(2008) EMBO rep., 9, 84-90
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S. Yamaguchi, S. Matsumoto, K. Ishizuka, Y. Iko, K.V. Tabata, H.F. Arata, H. Fujita, H. Noji and I. Hamachi
Thermally Responsive Supramolecular Nanomeshes for On/Off Switching of the Rotary Motion of F1-ATPase at the Single-Molecule Level.
(2008) Chem. Eur. J., 14, 1891-1896
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B. Le Pioufle, H. Suzuki, K.V. Tabata, H. Noji and S. Takeuchi
Lipid bilayer microarray for parallel recording of transmembrane ion currents.
(2008) Anal. Chem., 80, 328-832
published online

2007

L. Lam, S. Sakakihara, K. Ishizuka, S. Takeuchi and H. Noji
An integrated system for enzymatic cleavage and electrostretching of freely-suspended single DNA molecules.
(2007) Lab Chip, 7, 1738-1745
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K. Adachi, K. Oiwa, T. Nishizaka, S. Furuike, H. Noji, H. Itoh, M. Yoshida, K. Kinosita Jr.
Coupling of Rotation and Catalysis in F1-ATPase Revealed by Single-Molecule Imaging and Manipulation
(2007) Cell, 130, 309-321
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T. Nishinaka, Y. Doi, M. Hashimoto,R. Hara, T. Shibata, Y. Harada, K. KinositaJr, H. Noji and E. Yashima
Visualization of RecA filaments and DNA by fluorescence microscopy.
(2007) J. Biochem. (Tokyo), 141, 147-156
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2006

E. Muneyuki, T. Watanabe-Nakayama, T. Suzuki, M. Yoshida, T. Nishizaka and H. Noji
Single Molecule Energetics of F1-ATPase motor.
(2006) Biophys. J., 92, 1806-1812
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H.F. Arata, P. Low, K. Ishizuka, C. Bergaud, B. Kim, H. Noji and H. Fujita
Temperature distribution measurement on microfabricated thermodevice for single biomolecular observation using fluorescent dye.
(2006) Sens. Actuators B-Chem., 117, 339-345
published online

S.W. Lee, T. Yamamoto, H. Noji and T. Fujii
Chemical delivery microsystem for single-molecule analysis using multilaminar continuous flow.
(2006) Enzyme and Microb. Technol., 39, 519-525
published online

H.F. Arata, H. Noji and H. Fujita
Motion control of single F1-ATPase rotary biomolecular motor using microfabricated local heating devices.
(2006) Appl. Phys. Lett., 88, 083902
published online

H. Suzuki, K.V. Tabata, H. Noji and S. Takeuchi
Highly Reproducible Method of Planar Lipid Bilayer Reconstitution in Polymethyl Methacrylate Microfluidic Chip.
(2006) Langmuir, 22, 1937-1942
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2005

A.R. Laine, D. Okuno, K.V. Tabata, Y. Okada, A. Tixier-Mita, H. Noji and H. Fujita
Gold functionalized nano-needles for angular protein movement visualization.
(2005) Nanobiotechnology, 1, 227-236
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H.F. Arata, Y. Rondelez, H. Noji and H. Fujita
Temperature alternation by an on-chip microheater to reveal enzymatic activity of beta-galactosidase at high temperatures.
(2005) Anal. Chem., 77, 4810-4814
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Y. Hirono-Hara, K. Ishizuka, K. Kinosita Jr., M. Yoshida and H. Noji
Activation of pausing F1 motor by external force.
(2005) Proc. Natl. Acad. Sci. USA, 102, 4288-4293
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Y. Rondelez, G. Tresset, T. Nakashima, Y. Kato-Yamada, H. Fujita, S. Takeuchi and H. Noji
Highly coupled ATP synthesis by F1-ATPase single molecules.
(2005) Nature, 433, 773-777
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Y. Rondelez, G. Tresset, K.V. Tabata, H. Arata, H. Fujita, S. Takeuchi and H. Noji
Microfabricated arrays of femtoliter chambers allow single molecule enzymology
(2005) Nat. Biotech., 3, 361-365
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H. Noji, Y. Rondelez, T. Nakashima, G. Tresset, K.V. Tabata, Y. Kato-Yamada, H. Fujita and S. Takeuchi
Ultra-small chamber for single-molecule detection of biological reaction
(2005) e-J. Surf. Sci. Nanotech, 3, 79-81
published online

T. Ide, Y. Takeuchi, T. Aoki, K.V. Tabata and H. Noji
An artificial lipid bilayer formed on a PEG-coated glass for simultaneous electrical and optical measurement of single ion-channels.
(2005) e-J. Surf. Sci. Nanotech, 3, 70-73
published online

2004

H. Suzuki H., K.V. Tabata, Y. Kato-Yamada, H. Noji and S. Takeuchi
Planar lipid bilayer reconstitution with a micro-fluidic system
(2004) Lab chip, 502-505
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K. Atsuta, H. Noji and S. Takeuchi
Micro patterning of active proteins with perforated PDMS sheets (PDMS sieve)
(2004) Lab Chip, 4, 333-336
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H. Itoh, A. Takahashi, K. Adachi, H. Noji, R. Yasuda, M. Yoshida and K. Kinosita Jr.
Mechanically driven ATP synthesis by F1-ATPase.
(2004) Nature, 427, 465-468
published online

T. Nishizaka, K. Oiwa, H. Noji, S. Kimura, E. Muneyuki, M. Yoshida and K. KinositaJr.
Chemomechanical coupling in F1-ATPase revealed by simultaneous observation of nucleotide kinetics and rotation.
(2004) Nat. Struct. Mol. Biol., 11,142-148
published online

2003

S. Ono, K.Y. Hara, J. Hirao, T. Matsui, H. Noji, M. Yoshida and E. Muneyuki
Origin of apparent negative cooperativity of F1-ATPase.
(2004) Biochim. Biophys. Acta., 1607, 35-44

R. Yasuda, T. Masaike, K. Adachi, H. Noji and K. Kinosita Jr.
The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer.
(2004) Proc. Natl. Acad. Sci. USA, 100, 9314-9318
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H. Imamura, M. Nakano, H. Noji, E. Muneyuki, S. Ohkuma, M. Yoshida and K. Yokoyama
Evidence for rotation of V1-ATPase
(2004) Proc. Natl. Acad. Sci. USA, 100, 2312-2315
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2002

T. Ariga, T. Masaike, H. Noji and M. Yoshida
Stepping rotation of F1-ATPase with 1, 2, or 3 altered catalytic sites that bind ATP only slowly.
(2002) J. Biol. Chem., 277, 24870-24874
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T. Masaike, E. Muneyuki, H. Noji, K. Kinosita Jr. and M. Yoshida
F1-ATPase changes its conformations upon phosphate release.
(2002) J. Biol. Chem., 277, 21643-21649
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2001

Y. Hirono-Hara, H. Noji, M. Nishiura, E. Muneyuki, K.Y. Hara, R.Yasuda, K. Kinosita Jr. and M. Yoshida
Pause and rotation of F1-ATPase during catalysis.
(2002) Proc. Natl. Acad. Sci. USA, 98, 13649-13654
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D. Bald, H. Noji, M. Yoshida, Y. Hirono-Hara and T. Hisabori
Redox regulation of the rotation of F1-ATP synthase.
(2002) J. Biol. Chem., 276, 39505-7
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R. Yasuda, H. Noji, M. Yoshida, K. Kinosita Jr. and H. Itoh
Resolution of distinct rotational substeps by submillisecond kinetic analysis of F1-ATPase.
(2002) Nature, 410, 898-904

H. Noji, D. Bald, R. Yasuda, H. Itoh, M. Yoshida and K. Kinosita Jr.
Purine but not pyrimidine nucleotides support rotation of F1-ATPase.
(2002) J. Biol. Chem., 276, 25480-25486
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2000

K. Adachi, R. Yasuda, H. Noji, H. Itoh, Y. Harada, M. Yoshida and K. Kinosita Jr.
Stepping rotation of F1-ATPase visualized through angle-resolved single-fluorophore imaging.
(2000) Proc. Natl. Acad. Sci. USA, 97, 7243-7247
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K.Y. Hara, H. Noji, D. Bald, R. Yasuda, K. Kinosita Jr. and M. Yoshida
The role of the DELSEED motif of the beta subunit in rotation of F1-ATPase.
(2000) J. Biol. Chem., 275, 14260-14263
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D. Bald and H. Noji, M.T. Stumpp, M. Yoshida and T. Hisabori
ATPase activity of a highly stable 33 subcomplex of thermophilic F1 can be regulated by the introduced regulatory region of gamma subunit of chloroplast F1.
(2000) J. Biol. Chem., 275, 12757-12762
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S.P. Tsunoda, R. Aggeler, H. Noji, K. Kinosita Jr., M. Yoshida and R.A. Capaldi
R Observations of rotation within the FoF1-ATP synthase: deciding between rotation of the Foc subunit ring and artifact.
(2000) FEBS Lett., 470, 244-248

T. Masaike, N. Mitome, H. Noji, E. Muneyuki, R. Yasuda, K. Kinosita Jr. and M. Yoshida
Rotation of F1-ATPase and the hinge residues of the beta subunit.
(2000) J. Exp. Biol., 203, 1-8

1999

T. Amano, T. Matsui, E. Muneyuki, H. Noji, K. Hara, M. Yoshida and T. Hisabori
alpha3beta3gamma complex of F1-ATPase from thermophilic Bacillus PS3 can maintain steady-state ATP hydrolysis activity depending on the number of non-catalytic sites.
(1999) Biochem J., 343, 135-8.

H. Noji, K. Hasler, W. Junge, K. Kinosita Jr., M. Yoshida and S. Engelbrecht
Rotation of Escherichia coli F1-ATPase.
(1999) Biochem. Biophys. Res. Commun., 260, 597-599

S.P. Tsunoda, E. Muneyuki, T. Amano, M. Yoshida and H. Noji
Cross-linking of two beta subunits in the closed conformation in F1-ATPase.
(1999) J. Biol. Chem., 274, 5701-5706
PDF

1998

Y. Kato-Yamada, H. Noji, R. Yasuda, K. Kinosita Jr. and M. Yoshida
Direct observation of the rotation of epsilon subunit in F1-ATPase.
(1998) J. Biol. Chem., 273, 19375-19377
PDF

R. Yasuda, H. Noji, K. Kinosita Jr. and M. Yoshida
F1-ATPase is a highly efficient molecular motor that rotates with discrete 120 degree steps.
(1998) Cell, 93, 1117-1124

1997

H. Noji, R. Yasuda, M. Yoshida and K. Kinosita Jr.
Direct observation of the rotation of F1-ATPase.
(1997) Nature, 386, 299-302

2017

H. Noji, H. Ueno and D.G.G. Duncan
Catalytic robustness and torque generation of the F1-ATPase
(2017) Biophys. Rev., 9, 103-118
published online(リンク先)

2016

Y, Zhang and H. Noji
Digital bioassay: Theory, applications, and perspectives.
(2016) Anal. Chem., 89, 92-101
published online(リンク先)

2013

R. Watanabe and H. Noji
Chemomechanical coupling mechanism of F1-ATPase: Catalysis and torque generation
(2013) FEBS Lett., 587, 1030-1035
published online

R. Iino and H. Noji
Intersubunit coordination and cooperativity in ring-shaped NTPases
(2013) Curr. Opin. Struct. Biol., 23, 229-234
published online

R. Iino and H. Noji
Operation mechanism of FoF1-ATP synthase revealed by its structure and dynamics
(2013) IUBMB Life, 238-246
published online

2012

R. Iino and H. Noji
Rotary catalysis of the stator ring of F1-ATPase.
(2012) BBA – Bioenergetics, 1817, 1732-1739
published online

R. Iino, K. Nishino, H. Noji, A. Yamaguchi and Y. Matsumoto
A microfluidic device for simple and rapid evaluation of multidrug efflux pump inhibitors.
(2012) Front. Microbiol., 3, 40
published online

2011

D. Okuno, R. Iino and H. Noji
F1-ATPase: Fundamental properties and structure.
(2011) In “Encyclopedia of Biophysics” edited by Roberts G.C. Springer (India).

H. Noji, D. Okuno and T. Ikeda
Mechanochemistry of F1 motor protein.
(2011) Chem. Sci., DOI: 10.1039/C1SC00276G
PDF

D. Okuno, R. Iino and H. Noji
Rotation and Structure of FoF1-ATP synthase
(2011) J. Biochem., 149, 655-664
PDF

2010

D. Okuno, M. Ikeguchi and H. Noji
Measurement of the conformational state of F1-ATPase by single-molecule rotation
(2010) Methods Enzymol., 475, 279-296

2009

R. Iino, L. Lam, K.V. Tabata, Y. Rondelez, and H. Noji
Single-molecule assay of biological reaction in femtoliter chamber array
(2009) Jpn. J. Appl. Phys., 48, 08JA04
PDF

2008

R. Iino and H. Noji
Two rotary motors in ATP-synthase
“Single Molecule Dynamics in Life Science” Capter 10. Edited by Yanagida T and Ishii Y.
(2008) WILEY-VCH (Germany).

L. Lam, R. Iino, K.V. Tabata and H. Noji
Highly-sensitive Restriction Enzyme Assay and Analysis:
(2008) Anal. Bioanal. Chem., 391, 2423-2432

2006

R. Iino and H. Noji
F1-ATPase: a highly coupled reversible rotary motor.
(2006) Biochem. Soc. Trans., 34, 993-6

2005

R. Iino, Y. Rondelez, M. Yoshida and H. Noji
Chemomechanical coupling in single-molecule F-type ATP synthase.
(2005) J. Bioenerg. Biomembr., 37, 451-453

2003

H. Noji
F1-motor of ATP synthase.
Molucular Motors. M. Schilwa (ed.).
(2004) Wiley-VCH, 141-151

K. Adachi, H. Noji and K. Kinosita Jr.
Single-molecule imaging of rotation of F1-ATPase.
(2004) Methods Enzymol., 361, 211-227

2002

H. Noji
Molecular mechanism of torque generation in F1-motor
(2002) Tanpakushitsu Kakusan Koso, 47, 1174-1181

2001

H. Noji and M. Yoshida
The rotary machine in the cell, ATP synthase.
(2002) J. Biol. Chem., 276, 1665-1668

2000

K. Kinosita Jr., R. Yasuda and H. Noji
F1-ATPase: a highly efficient rotary ATP machine.
(2000) Essays Biochem., 35, 3-18

E. Muneyuki, H. Noji, T. Amano, T. Masaike and M. Yoshida
F0F1-ATP synthase: general structural features of 'ATP-engine' and a problem on free energy transduction.
(2000) Biochim. Biophys. Acta., 1458, 467-841

K. Kinosita Jr., R. Yasuda, H. Noji and K. Adachi
A rotary molecular motor that can work at near 100% efficiency.
(2000) Philos. Trans. R Soc. Lond. B Biol. Sci., 355, 473-89

T. Masaike, N. Mitome, H. Noji, E. Muneyuki, R. Yasuda, K. Kinosita Jr. and M. Yoshida
Rotation of F1-ATPase and the hinge residues of the beta subunit.
(2000) J. Exp. Biol., 203, 1-8

1999

H. Noji and M. Yoshida
F1-ATPase; the stepping rotary motor in ATP synthase
(1999) Seikagaku, 71, 34-50

1998

H. Noji
The rotary enzyme of the cell: the rotation of F1-ATPase.
(1998) Science, 282:1844-5

K. Kinosita Jr., R. Yasuda, H. Noji, S. Ishiwata and M. Yoshida
F1-ATPase: a rotary motor made of a single molecule.
(1998) Cell, 93, 21-24

1997

R. Yasuda, H. Noji, K. Kinosita Jr., F. Motojima and M. Yoshida
Rotation of the gamma subunit in F1-ATPase; evidence that ATP synthase is a rotary motor enzyme.
(1997) J. Bioenerg. Biomembr., 29, 207-209

M. Yoshida, H. Noji and E. Muneyuki
World smallest motor, ATP synthase
(1997) Tanpakushitsu Kakusan Koso., 42, 1396-406

1996

H. Noji, T. Amano and M. Yoshida
Molecular switch of F0F1-ATP synthase, G-protein, and other ATP-driven enzymes.
(1996) J. Bioenerg. Biomembr., 28, 451-457

野地研究室 Single Molecule Biophysics Noji Laboratory